2,6-Difluoro-4-[4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl]phenol
LJH685
CAS: 1627710-50-2
Molecular Formula: C22H21F2N3O
2,6-Difluoro-4-[4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl]phenol - Names and Identifiers
2,6-Difluoro-4-[4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl]phenol - Physico-chemical Properties
| Molecular Formula | C22H21F2N3O |
| Molar Mass | 381.42 |
| Density | 1.257±0.06 g/cm3(Predicted) |
| Boling Point | 481.1±45.0 °C(Predicted) |
| Solubility | DMSO: ≥ 31 mg/mL |
| pKa | 5.86±0.25(Predicted) |
| Storage Condition | -20℃ |
2,6-Difluoro-4-[4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl]phenol - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.622 ml | 13.109 ml | 26.218 ml |
| 5 mM | 0.524 ml | 2.622 ml | 5.244 ml |
| 10 mM | 0.262 ml | 1.311 ml | 2.622 ml |
| 5 mM | 0.052 ml | 0.262 ml | 0.524 ml |
Last Update：2024-01-02 23:10:35
2,6-Difluoro-4-[4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl]phenol - Reference Information
| biological activity | LJH685 is a potent, selective, ATP-competitive RSK inhibitor, inhibition of RSK1/2/3 biological activity, IC50 6, 5, 4 nM. |
| Target | IC50: 6 nM (RSK1), 5 nM (RSK1), 4 nM (RSK1) |
| Cell Line: | MDA-MB-231, H358 cells MDA-MB-231, H358 cells |
| Concentration: | 0.01, 0.1, 1, 10, 100 μM 0.1, 0.3, 1, 3, 10 μM |
| Incubation Time: | 72 hours 4 hours |
| Result: | The growth in soft agar was efficiently inhibited with EC 50 values of 0.73 and 0.79 μM in MDA-MB-231 and H358, respectively. Efficiently reduced phosphorylation of YB1 at submicromolar concentrations and caused nearly complete inhibition at higher concentrations. |
Last Update：2024-04-10 22:29:15
![2,6-Difluoro-4-[4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl]phenol](http://res.chembk.com/assets/str/2d/1/16/1627710-50-2.png)
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Product Name: LJH685 Visit Supplier Webpage Request for quotation
CAS: 1627710-50-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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CAS: 1627710-50-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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